Not in the conventional sense. However, there are options to achieve this:

  1. For Room or Space work planes, you can only trim the grid of points around the edges by increasing the “Boundary Offset” from the Advanced section of the calculation points dialog.
  2. The preferred solution is to use a Revit Filled Region as the calculation point boundary instead of a Room or Space. Regions can have holes and the calculation points will not appear in the holes. 

An illustrated process is available at this link.